Micronized

Micronized is a term used in the pharmaceutical industry to refer to the reduction of particle size of a solid drug substance to a few micrometres or less. This process is achieved through a variety of mechanical and chemical methods, and is used to increase the surface area of the drug, thereby enhancing its dissolution rate and bioavailability.

Process

The process of micronization involves the use of specialized equipment such as jet mills, ball mills, and high-pressure homogenization. These methods utilize high velocity, pressure, or shear to reduce the particle size of the drug substance. The choice of method depends on the properties of the drug substance and the desired particle size.

Benefits

Micronization offers several benefits in the formulation of pharmaceutical products. By increasing the surface area of the drug, it enhances the dissolution rate and bioavailability of the drug, which can lead to improved therapeutic effects. It can also improve the stability of the drug and allow for more precise dosage control.

Applications

Micronization is used in a wide range of pharmaceutical applications. It is commonly used in the formulation of oral dosage forms such as tablets and capsules, as well as parenteral products. It is also used in the production of inhalable drugs, where small particle size is critical for effective drug delivery to the lungs.

See also

• Pharmaceutical formulation
• Drug delivery
• Particle size analysis

Micronized Resources
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