Minaprine
Minaprine[edit | edit source]
Minaprine is a psychotropic drug that was primarily used as an antidepressant in the treatment of major depressive disorder. It was developed in the 1980s and marketed in several countries, although it is not widely used today. Minaprine is known for its unique pharmacological profile, which includes both monoamine oxidase inhibition and serotonin receptor modulation.
Pharmacology[edit | edit source]
Minaprine acts as a reversible inhibitor of monoamine oxidase A (RIMA), which is an enzyme responsible for the breakdown of monoamines such as serotonin, norepinephrine, and dopamine. By inhibiting this enzyme, Minaprine increases the levels of these neurotransmitters in the brain, which can help alleviate symptoms of depression.
In addition to its action on monoamine oxidase, Minaprine also interacts with various serotonin receptors, particularly the 5-HT2 receptor. This interaction is thought to contribute to its antidepressant effects and may also influence its side effect profile.
Clinical Use[edit | edit source]
Minaprine was used in the treatment of major depressive disorder, particularly in cases where patients did not respond to other antidepressants. It was considered to have a relatively favorable side effect profile compared to some other antidepressants available at the time.
Side Effects[edit | edit source]
Common side effects of Minaprine included nausea, headache, and insomnia. Some patients also reported dizziness and dry mouth. As with other antidepressants, there was a risk of serotonin syndrome if Minaprine was taken in combination with other serotonergic drugs.
Synthesis[edit | edit source]
The synthesis of Minaprine involves several chemical reactions starting from basic organic compounds. The process typically includes the formation of the core structure followed by the addition of various functional groups to achieve the final active compound. The detailed synthesis pathway is illustrated in the accompanying diagram.
Discontinuation[edit | edit source]
Minaprine was eventually withdrawn from the market in several countries due to concerns about its safety and the availability of newer antidepressants with improved efficacy and safety profiles. However, it remains a compound of interest in pharmacological research due to its unique mechanism of action.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD