Mirikizumab
Mirikizumab is an experimental monoclonal antibody designed for the treatment of psoriasis, ulcerative colitis, and Crohn's disease. It is developed by Eli Lilly and Company.
Mechanism of action[edit | edit source]
Mirikizumab works by targeting interleukin 23, a molecule that plays a key role in inflammatory processes of the immune system and is thought to be linked to a number of chronic immune diseases, including psoriasis and ulcerative colitis.
Clinical trials[edit | edit source]
Phase 2 trials for psoriasis showed promising results for mirikizumab. Most patients in the trial achieved significant skin clearance, with a clear or almost clear skin rating of 0/1 on the Psoriasis Area and Severity Index (PASI), and a 90% reduction in the PASI score (PASI 90).
Mirikizumab has also undergone Phase 2 trials for ulcerative colitis. Results indicated that the drug was well tolerated and met the primary endpoint of the study.
Development[edit | edit source]
The development of mirikizumab is being carried out by Eli Lilly and Company. The drug is currently in Phase 3 clinical trials.
See also[edit | edit source]
- List of investigational drugs
- Monoclonal antibodies (mAbs)
- Interleukin 23
- Psoriasis
- Ulcerative colitis
- Crohn's disease
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