Mitochondrial dicarboxylate carrier

Mitochondrial Dicarboxylate Carrier (also known as SLC25A10 or DIC) is a protein that in humans is encoded by the SLC25A10 gene. It is a member of the SLC25 family of mitochondrial carrier proteins, which are responsible for the transport of metabolites across the mitochondrial inner membrane.

Function

The mitochondrial dicarboxylate carrier is involved in the transport of dicarboxylates across the inner mitochondrial membrane. Dicarboxylates are important for the citric acid cycle, also known as the Krebs cycle, which is a key metabolic pathway that connects carbohydrate, fat, and protein metabolism. The reactions of the citric acid cycle are carried out by eight enzymes that completely oxidize acetate, in the form of acetyl-CoA, into two molecules each of carbon dioxide and water.

Structure

The SLC25A10 gene is located on the long (q) arm of chromosome 17 at position 21.2. The protein encoded by this gene is a member of the mitochondrial carrier family and was identified by its ability to functionally complement mutations in the yeast dicarboxylate carrier. The sequence of the human protein is 88% identical to the yeast protein at the amino acid level.

Clinical significance

Mutations in the SLC25A10 gene have been associated with a form of metabolic acidosis, characterized by an accumulation of dicarboxylates in the blood. This condition can lead to various symptoms, including fatigue, rapid breathing, and loss of appetite.

See also

• SLC25 family
• Mitochondrial carrier
• Citric acid cycle