Mitochondrial ribosomal protein L13

Mitochondrial ribosomal protein L13 (MRPL13) is a protein that in humans is encoded by the MRPL13 gene. This protein is a component of the mitochondrial ribosome, which is responsible for protein synthesis within the mitochondria.

Function

MRPL13 is one of the proteins that make up the large subunit of the mitochondrial ribosome. It plays a crucial role in the protein synthesis process within the mitochondria, the powerhouses of the cell. The protein is involved in the translation of mitochondrial mRNA into functional proteins, which are essential for the normal functioning of the mitochondria and, by extension, the cell.

Structure

The MRPL13 protein is a small protein with a molecular weight of approximately 13 kDa. It is composed of 117 amino acids and has a predicted isoelectric point of 10.5. The protein has a highly conserved sequence, suggesting that it plays a vital role in mitochondrial function.

Clinical significance

Mutations in the MRPL13 gene have been associated with various mitochondrial disorders. These disorders are characterized by a wide range of symptoms, including muscle weakness, neurological problems, and organ dysfunction. The exact role of MRPL13 in these disorders is still under investigation.

See also

• Mitochondrial ribosome
• Mitochondrial diseases
• Protein synthesis
• Gene

External links

• MRPL13 at the National Center for Biotechnology Information