N-Phenethylnormorphine
N-Phenethylnormorphine is a semi-synthetic opioid compound and a derivative of morphine. It is a potent analgesic that has been used in the treatment of severe pain.
Chemistry[edit | edit source]
N-Phenethylnormorphine is a morphine derivative where the N-methyl group is replaced by a phenethyl group. This modification results in a compound with a higher potency and a longer duration of action compared to morphine.
Pharmacology[edit | edit source]
Like other opioids, N-Phenethylnormorphine works by binding to and activating the mu-opioid receptor in the central nervous system. This results in an analgesic effect, as well as other effects such as sedation, euphoria, and respiratory depression.
Clinical Use[edit | edit source]
N-Phenethylnormorphine has been used in the treatment of severe pain, such as that associated with cancer or major surgery. However, its use is limited by its potential for addiction and the development of tolerance.
Side Effects[edit | edit source]
The side effects of N-Phenethylnormorphine are similar to those of other opioids and can include nausea, vomiting, constipation, and respiratory depression. In addition, long-term use can lead to the development of physical dependence and addiction.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD