NABP1

NABP1 (Nucleic Acid Binding Protein 1), also known as SOSS-B1 (Sensor of Single-Strand DNA complex B1), is a protein that in humans is encoded by the NABP1 gene. It is involved in the recognition and repair of damaged DNA, and plays a crucial role in maintaining the stability of the human genome.

Function

NABP1 is a member of the SOSS complex, which is a multiprotein complex involved in the recognition of single-stranded DNA (ssDNA) and activation of ATM kinase, a key player in the cellular response to DNA damage. The SOSS complex is thought to promote DNA repair by stabilizing the RAD51 and BRCA2 proteins at sites of DNA damage.

Clinical significance

Mutations in the NABP1 gene have been associated with an increased risk of developing certain types of cancer, including breast cancer and ovarian cancer. This is likely due to the role of NABP1 in DNA repair and genome stability.

Research

Research into the function and structure of NABP1 is ongoing, with a focus on understanding its role in DNA repair and its potential as a target for cancer therapy.

See also

• SOSS complex
• ATM kinase
• RAD51
• BRCA2

References

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