NAIP (gene)

NAIP (Neuronal Apoptosis Inhibitory Protein) is a protein that in humans is encoded by the NAIP gene. It is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death.

Function

The NAIP gene is part of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. NAIP is known to interact with, and inhibit four members of the caspase family of cell-death proteases: caspase-3, -7, -9, and -1. The NAIP gene is located within the chromosome 5q13 region, and is associated with spinal muscular atrophy (SMA).

Clinical significance

Mutations in the NAIP gene are associated with a pre-disposition to neurodegenerative diseases, including spinal muscular atrophy (SMA). SMA is a disease that causes progressive degeneration of the motor neurons of the spinal cord, leading to muscular weakness and atrophy.

Research

Research into the NAIP gene and its associated protein has potential implications for the treatment of neurodegenerative diseases. By understanding the mechanisms by which NAIP inhibits apoptosis, it may be possible to develop therapies that can slow or halt the progression of diseases like SMA.

See also

• Inhibitor of apoptosis
• Spinal muscular atrophy
• Neurodegenerative diseases
• Caspase