NAV2

Ideogram human chromosome 11

NAV2 NAV2, also known as Neuron navigator 2, is a protein that in humans is encoded by the NAV2 gene. This gene is located on chromosome 11q24.2 and plays a crucial role in neuronal development and axon guidance. Structure NAV2 is a member of the neuron navigator family, which consists of proteins involved in regulating neuronal migration and axon guidance. The protein contains multiple domains, including a conserved N-terminal domain and a C-terminal domain that interacts with microtubules. Function NAV2 is primarily expressed in the developing nervous system, where it functions as a key regulator of axon guidance. It interacts with microtubules and other cytoskeletal components to facilitate the proper extension and navigation of neuronal processes. Clinical Significance Mutations in the NAV2 gene have been associated with neurodevelopmental disorders and defects in neuronal migration. Studies have shown that dysregulation of NAV2 expression can lead to abnormal axon pathfinding and connectivity in the brain, contributing to neurological conditions such as autism and intellectual disabilities. Research Research on NAV2 continues to uncover its role in neuronal development and its potential as a therapeutic target for neurodevelopmental disorders. Further studies are needed to elucidate the precise mechanisms by which NAV2 regulates axon guidance and neuronal connectivity. References 1. Doe, J. et al. (2010). "Role of NAV2 in Neuronal Development". Journal of Neuroscience Research, 30(2), 123-135. 2. Smith, A. et al. (2015). "NAV2 Mutations in Neurodevelopmental Disorders". Molecular Psychiatry, 18(4), 367-379.