NCOA7

NCOA7 (Nuclear Receptor Coactivator 7) is a protein that in humans is encoded by the NCOA7 gene.

Function

NCOA7 is a member of the nuclear receptor coactivator family. These coactivators are proteins that interact with nuclear receptors to enhance their transcriptional activity. NCOA7 is known to interact with several nuclear receptors, including the estrogen receptor, and is involved in the regulation of gene expression in response to hormonal signals.

Structure

The NCOA7 protein contains several domains that are important for its function as a coactivator. These include LXXLL motifs, which are known to mediate interactions with nuclear receptors. The structure of NCOA7 allows it to function as a bridge between nuclear receptors and the transcriptional machinery, facilitating the transcription of target genes.

Clinical Significance

Alterations in the expression or function of NCOA7 have been implicated in various diseases. For example, changes in NCOA7 expression levels have been observed in certain types of cancer, suggesting a potential role in tumorigenesis. Further research is needed to fully understand the clinical implications of NCOA7 dysregulation.

Interactions

NCOA7 has been shown to interact with several proteins, including:

• Estrogen receptor alpha (ERα)
• Nuclear receptor coactivator 1 (NCOA1)

These interactions are crucial for its role in modulating the activity of nuclear receptors and influencing gene expression.

Research

Ongoing research is focused on elucidating the precise mechanisms by which NCOA7 influences nuclear receptor activity and its potential as a therapeutic target in diseases such as cancer.

See Also

• Nuclear receptor coactivator
• Gene expression
• Estrogen receptor

External Links

• NCOA7 Gene - NCBI
• NCOA7 Protein - UniProt