Tumorigenesis
Tumorigenesis is the process through which normal cells transform into cancer cells. This process is characterized by a series of changes at the cellular, genetic, and epigenetic levels that ultimately reprogram a cell to undergo uncontrolled cell division, leading to the formation of a malignant tumor.
Overview[edit | edit source]
Tumorigenesis is a complex process that involves multiple stages. These stages include initiation, promotion, and progression. During the initiation stage, a cell's DNA is damaged, which can lead to mutations. The promotion stage involves the expansion of these mutated cells, and the progression stage is characterized by the acquisition of invasive properties.
Genetic Changes[edit | edit source]
Genetic changes are a key factor in tumorigenesis. These changes can occur in two types of genes: oncogenes and tumor suppressor genes. Oncogenes are genes that, when mutated or overexpressed, have the potential to cause normal cells to become cancerous. Tumor suppressor genes are genes that protect a cell from one step on the path to cancer. When these genes are altered, cancer can occur.
Epigenetic Changes[edit | edit source]
In addition to genetic changes, epigenetic changes also play a crucial role in tumorigenesis. These changes involve modifications to the DNA molecule itself, but do not involve a change in the DNA sequence. Epigenetic changes can lead to the activation of oncogenes or the inactivation of tumor suppressor genes.
Role of the Microenvironment[edit | edit source]
The tumor microenvironment is the environment around a tumor, including the surrounding blood vessels, immune cells, fibroblasts, and other cells. This microenvironment plays a crucial role in tumorigenesis. Changes in the microenvironment can promote tumor growth and progression.
Prevention and Treatment[edit | edit source]
Prevention and treatment of tumorigenesis involve targeting the genetic and epigenetic changes that drive the process. This can be achieved through various strategies, including chemotherapy, radiation therapy, and immunotherapy. In addition, lifestyle modifications, such as a healthy diet and regular exercise, can also help prevent tumorigenesis.
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Contributors: Prab R. Tumpati, MD
