NDFIP1

NEDD4 family interacting protein 1 (NDFIP1) is a protein that in humans is encoded by the NDFIP1 gene. This protein is involved in various cellular processes, including the regulation of ubiquitin-mediated protein degradation.

Function

NDFIP1 is a member of the NEDD4 family of E3 ubiquitin-protein ligase adaptors. It plays a crucial role in the regulation of protein turnover by facilitating the ubiquitination and subsequent degradation of target proteins. NDFIP1 is known to interact with several members of the NEDD4 family, including NEDD4, NEDD4L, and ITCH.

Clinical Significance

Mutations or dysregulation of NDFIP1 have been implicated in various diseases, including autoimmune disorders and cancer. The protein's role in the immune system is particularly significant, as it helps regulate the degradation of proteins involved in T-cell activation and inflammation.

Interactions

NDFIP1 interacts with several proteins, including:

• NEDD4
• ITCH
• SMURF1

These interactions are important for the regulation of protein ubiquitination and degradation pathways.

See Also

• Ubiquitin-proteasome system
• Protein degradation
• E3 ubiquitin ligase

External Links

• NDFIP1 Gene - NCBI
• NDFIP1 - UniProt