NFATC3

NFATC3 (Nuclear Factor of Activated T-Cells, Cytoplasmic 3) is a protein that in humans is encoded by the NFATC3 gene.

Function

NFATC3 is a member of the nuclear factor of activated T-cells (NFAT) family of transcription factors. These transcription factors are involved in the regulation of gene expression in response to calcium signaling. NFAT proteins are critical for the development and function of the immune system, particularly in the activation of T-cells.

Structure

The NFATC3 protein contains several domains that are important for its function, including a Rel homology domain (RHD) that is responsible for DNA binding and a transactivation domain that interacts with other proteins to regulate transcription.

Clinical Significance

Mutations or dysregulation of NFATC3 have been implicated in various diseases, including autoimmune disorders and cancer. Research is ongoing to better understand the role of NFATC3 in these conditions and to develop potential therapeutic strategies.

Interactions

NFATC3 interacts with several other proteins to exert its effects on gene expression. It can form complexes with other NFAT family members, as well as with AP-1 transcription factors, to regulate the expression of target genes.

See Also

• NFATC1
• NFATC2
• NFATC4
• Transcription factor
• T-cell receptor

External Links

• NFATC3 Gene - NCBI
• NFATC3 Protein - UniProt