NFATC2

NFATC2 (Nuclear Factor of Activated T-cells, Cytoplasmic 2) is a protein that in humans is encoded by the NFATC2 gene. It is a member of the NFAT family of transcription factors, which play a crucial role in the immune response.

Function

NFATC2 is a component of the calcineurin-NFAT signaling pathway, which is involved in T cell activation. Upon T cell receptor (TCR) stimulation, NFATC2 is dephosphorylated by calcineurin, leading to its nuclear translocation where it activates the transcription of target genes.

Clinical significance

Alterations in the NFATC2 gene have been associated with various diseases. For example, mutations in this gene have been linked to autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. Additionally, overexpression of NFATC2 has been observed in several types of cancer, including breast cancer and colorectal cancer.

Research

Research on NFATC2 is ongoing, with studies focusing on its role in immune response, its potential as a therapeutic target in autoimmune diseases and cancer, and its involvement in other biological processes.

See also

• NFAT
• T cell
• Autoimmune disease
• Cancer