NFIC (gene)

NFIC (Nuclear Factor I C) is a gene that encodes a protein in humans. It is also known as CTF, CTF1, NF-I/C, and NFI-C. The NFIC gene is located on the short (p) arm of chromosome 19 at position 13.3.

Function

The NFIC gene provides instructions for making a protein that is part of a family of proteins known as nuclear factor I (NFI). These proteins bind to DNA and control the activity of other genes. The NFIC protein is involved in the development and function of the tooth and bone.

Clinical significance

Mutations in the NFIC gene have been associated with tooth agenesis, a condition characterized by the absence of one or more teeth. These mutations can affect the function of the NFIC protein, leading to abnormal tooth development.

See also

• Nuclear factor 1
• Tooth agenesis

External links

• NFIC gene on the US National Library of Medicine website
• NFIC gene on the Genetics Home Reference website