NFIL3

NFIL3 (also known as Nuclear Factor, Interleukin 3 Regulated) is a protein that in humans is encoded by the NFIL3 gene. This protein is a transcription factor that plays a crucial role in the regulation of immune response and circadian rhythm.

Function

NFIL3 is a transcription factor that binds to the interleukin-3 promoter and plays a key role in immune response. It is also involved in the regulation of circadian rhythms in mammals. NFIL3 protein is expressed in a circadian manner and it regulates the oscillatory expression of several key clock genes.

Clinical significance

Alterations in the NFIL3 gene have been associated with a variety of medical conditions. For example, a lack of NFIL3 has been linked to an increased susceptibility to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Additionally, mutations in the NFIL3 gene have been implicated in some cases of insomnia and other sleep disorders.

Research

Research into the NFIL3 gene and its associated protein continues to be a significant focus in the fields of immunology and chronobiology. Understanding the precise mechanisms by which NFIL3 regulates immune response and circadian rhythms could lead to new treatments for a variety of conditions.

See also

• Transcription factor
• Interleukin-3
• Circadian rhythm
• Autoimmune disease