NKX2-3

NKX2-3 is a gene that provides instructions for making a protein that plays a crucial role in the development of the spleen, gut, and cardiac system. This protein belongs to the NKX family of homeodomain transcription factors, which are involved in the regulation of gene expression and cell differentiation during embryonic development.

Function

The NKX2-3 protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. Researchers believe that the NKX2-3 protein is involved in the formation and maintenance of the spleen and the development of the gut and the cardiac system.

Clinical significance

Mutations in the NKX2-3 gene have been associated with congenital heart disease and spleen disorders, including asplenia and polysplenia. These conditions are characterized by abnormalities in the structure and function of the heart and spleen, respectively.

Research

Research is ongoing to understand the precise role of the NKX2-3 gene in human health and disease. Understanding the function of this gene could lead to new treatments for congenital heart disease and spleen disorders.

See also

• Homeobox
• Transcription factor
• Congenital heart disease
• Asplenia
• Polysplenia