NO-711
NO-711 is a GABA reuptake inhibitor used in scientific research. It is one of the most commonly used GABA reuptake inhibitors and has been widely used in studies investigating the role of GABA in the brain and spinal cord.
Pharmacology[edit | edit source]
NO-711 works by blocking the GABA transporter 1 (GAT-1), a protein that removes GABA from the synaptic cleft. By inhibiting GAT-1, NO-711 increases the amount of GABA available to bind to GABA receptors, enhancing GABAergic neurotransmission.
Uses[edit | edit source]
NO-711 is not used clinically, but it is a valuable tool in neuroscience research. It has been used in studies investigating the role of GABA in various neurological and psychiatric disorders, including epilepsy, anxiety disorders, and schizophrenia. It has also been used in studies investigating the mechanisms of anesthesia and sleep.
Side Effects[edit | edit source]
As a research tool, NO-711 is not typically administered to humans, so its side effect profile is not well known. However, excessive GABAergic activity can lead to sedation, respiratory depression, and ataxia.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
