NRN1

NRN1 or Neuritin 1 is a protein that in humans is encoded by the NRN1 gene. It is a glycosylphosphatidylinositol (GPI)-linked protein that is associated with the nervous system.

Function

Neuritin 1 is a protein that is induced by neuronal activity. It is synthesized as a GPI-anchored molecule and is released by neurons in an activity-dependent manner. The released neuritin 1 promotes neurite outgrowth and neuronal survival.

Clinical significance

Alterations in the expression of this gene can affect the development and function of the nervous system. For example, decreased expression of NRN1 has been associated with schizophrenia and depression. On the other hand, overexpression of NRN1 has been linked to neuroblastoma, a type of cancer that develops from immature nerve cells.

Research

Research on NRN1 is ongoing, with studies investigating its role in various neurological disorders and its potential as a therapeutic target. For instance, a study published in the Journal of Neuroscience found that neuritin 1 can promote the survival of hippocampal neurons, suggesting a potential role in treating neurodegenerative diseases.

See also

• Neuritin
• Neurite
• Neuronal activity
• Neurodegenerative diseases