NXL103
NXL103 (formerly XRP 2868) is an experimental drug candidate under development by Novexel. It is an oral streptogramin antibiotic that has potent in vitro activity against certain Gram positive bacteria including methicillin resistant Staphylococcus aureus (MRSA) as well as the important respiratory pathogens including penicillin-, macrolide- and quinolone-resistant strains.[1][2] It is a combination of linopristin and flopristin.[3]
Clinical trials[edit | edit source]
Positive results have been reported from a phase II trial comparing it with amoxicillin.[1] Another phase II trial will be run in 2010 comparing it with linezolid for treatment of acute bacterial skin and skin structure infections (ABSSSI).[4]
References[edit | edit source]
- ↑ 1.0 1.1 Novexel Reports Positive Phase II Trial Results With NXL103 in Adult Patients With Community Acquired Pneumonia, drugs.com
- ↑ , Effects of various media on the activity of NXL103 (formerly XRP 2868), a new oral streptogramin, against Haemophilus influenzae, Antimicrobial agents and chemotherapy, 2006, Vol. 50(Issue: 11), pp. 3914–6, DOI: 10.1128/AAC.00587-06, PMID: 17065630, PMC: 1635171,
- ↑ NXL103 at Novexel.com
- ↑ Comparative Study of NXL103 Versus Linezolid in Adults With Acute Bacterial Skin and Skin Structure Infections (ABSSSI), clinicaltrials.gov
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