Linopristin/flopristin
Linopristin/Flopristin is a combination of two antibiotics, linopristin and flopristin, used in the treatment of infections caused by Gram-positive bacteria. It is marketed under the brand name Synercid.
Mechanism of Action[edit | edit source]
The combination of linopristin and flopristin works by inhibiting the protein synthesis of bacteria. Linopristin binds to the 50S subunit of the bacterial ribosome, preventing the formation of a functional 70S initiation complex. Flopristin binds at a nearby site, causing a conformational change that enhances the binding of linopristin. This dual action results in a synergistic bactericidal effect.
Indications[edit | edit source]
Linopristin/flopristin is indicated for the treatment of serious or life-threatening infections caused by vancomycin-resistant Enterococcus faecium (VREF) bacteremia. It is also used for skin and skin structure infections caused by Staphylococcus aureus (methicillin-susceptible strains) or Streptococcus pyogenes.
Side Effects[edit | edit source]
Common side effects of linopristin/flopristin include nausea, vomiting, diarrhea, rash, and pain or inflammation at the injection site. Serious side effects may include allergic reactions, thrombophlebitis, and superinfection.
Contraindications[edit | edit source]
Linopristin/flopristin is contraindicated in patients with known hypersensitivity to either linopristin or flopristin or any component of the formulation.
Drug Interactions[edit | edit source]
Linopristin/flopristin may interact with other drugs, including warfarin, cyclosporine, and digoxin. Therefore, caution should be exercised when co-administering these drugs.
Dosage and Administration[edit | edit source]
The recommended dosage of linopristin/flopristin is 7.5 mg/kg every 8 hours, administered by intravenous infusion over 60 minutes.
See Also[edit | edit source]
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