Neoantigen

Neoantigen

A Neoantigen is a type of antigen that has not been previously recognized by the immune system. They are often associated with cancers and viral infections, and are the result of DNA mutations in the cells of the body. Neoantigens can be targeted by the immune system, and are therefore of interest in the development of cancer immunotherapy treatments.

Overview

Neoantigens are unique to each individual's tumor, and are not present in normal tissues. This makes them an ideal target for cancer immunotherapies, as they can be targeted without causing damage to healthy tissues. Neoantigens are produced as a result of DNA mutations in cancer cells, which lead to the production of new proteins that are not recognized by the immune system.

Role in Cancer Immunotherapy

In cancer immunotherapy, the goal is to stimulate the immune system to recognize and attack cancer cells. One way to do this is by targeting neoantigens. By identifying the unique neoantigens present in a patient's tumor, it is possible to develop a personalized treatment that specifically targets those neoantigens.

There are several methods for identifying neoantigens, including genomic sequencing and proteomic analysis. Once the neoantigens have been identified, they can be used to create a vaccine or to engineer T cells that can recognize and attack the cancer cells.

Research and Development

Research into neoantigens and their role in cancer immunotherapy is ongoing. Several clinical trials are currently underway to test the effectiveness of neoantigen-based therapies. These trials are exploring a variety of approaches, including neoantigen vaccines, T cell therapies, and combination therapies.

See Also

• Cancer immunotherapy
• Antigen
• T cell
• DNA mutation

References

Neoantigen Resources
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