Neoendorphin

Neoendorphin is a type of neuropeptide that is found in the central nervous system and the peripheral nervous system. It is a member of the endorphin family, which are peptides that function as neurotransmitters. Neoendorphin is known to have a role in pain modulation and regulation of body temperature.

Structure and Function

Neoendorphin is composed of amino acids, the building blocks of proteins. It is synthesized in the body from the precursor protein proopiomelanocortin (POMC). The structure of neoendorphin is similar to that of other endorphins, with a core structure of a phenylalanine residue followed by a glycine residue.

The function of neoendorphin is primarily related to its role as a neurotransmitter. It binds to opioid receptors in the brain and spinal cord, leading to a decrease in the perception of pain. This is similar to the action of other endorphins, such as beta-endorphin and dynorphin. In addition to its role in pain modulation, neoendorphin is also involved in the regulation of body temperature.

Clinical Significance

The role of neoendorphin in pain modulation has led to interest in its potential use in the treatment of chronic pain conditions. However, the use of neoendorphin as a therapeutic agent is currently limited by its short half-life in the body and the potential for development of tolerance and dependence.

In addition to its role in pain, research has suggested that neoendorphin may also be involved in the regulation of mood and anxiety. This has led to interest in the potential use of neoendorphin in the treatment of mood disorders and anxiety disorders.

See Also

• Endorphin
• Neuropeptide
• Opioid receptor
• Proopiomelanocortin

References

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