Netrin receptor DCC

Netrin receptor DCC is a protein that in humans is encoded by the DCC gene. DCC stands for deleted in colorectal carcinoma. It is a tumor suppressor gene, and its loss of function is implicated in many types of cancer, including colorectal cancer.

Function

The DCC gene product is a transmembrane protein that is integral in guiding developing neurons to their appropriate positions in the brain. This is achieved through its interaction with netrin 1, a diffusible axon guidance protein. The DCC gene product is also involved in the induction of apoptosis, or programmed cell death.

Clinical significance

Alterations in the DCC gene are associated with a variety of cancers. Most notably, it is often deleted in colorectal cancer. This is due to the gene's role as a tumor suppressor. When functioning normally, the DCC gene product prevents the uncontrolled growth of cells. However, when the gene is deleted or mutated, this control is lost, leading to the development of cancer.

See also

• Netrin
• Tumor suppressor gene
• Colorectal cancer

External links

• DCC at the US National Library of Medicine Medical Subject Headings (MeSH)