Network of Cancer Genes

Network of Cancer Genes (NCG) is a comprehensive online repository that compiles and annotates genes involved in cancer. It aims to provide an integrated platform for the analysis of cancer genes, facilitating research and development in oncology and related fields. The NCG database includes information on cancer genes, their functions, and their relevance in various types of cancer, making it a valuable resource for researchers, clinicians, and students interested in cancer biology.

Overview

The Network of Cancer Genes focuses on the collection, curation, and analysis of genes that have been implicated in cancer. It leverages data from scientific literature, existing databases, and high-throughput experiments to identify and catalog cancer-associated genes. The database provides insights into the molecular mechanisms of cancer, offering a detailed view of the genetic alterations that drive tumorigenesis.

Content and Features

NCG includes detailed annotations for each cancer gene, such as its role in cancer, mutation types, and associated pathways. It also offers tools for the analysis of gene networks, enabling users to explore the interactions between cancer genes and their impact on cellular processes. The database is regularly updated to incorporate the latest research findings, ensuring that it remains a current and comprehensive resource.

Gene Annotations

Each gene in the NCG database is annotated with information about its involvement in cancer, including:

• Gene name and symbol
• Mutation types (e.g., missense, nonsense, frameshift)
• Associated cancer types
• Biological pathways and processes involved

Analysis Tools

NCG provides various tools for the analysis of cancer genes and their networks, such as:

• Network visualization to explore gene interactions
• Functional enrichment analysis to identify overrepresented biological processes
• Comparative analysis to study gene conservation across species

Applications

The Network of Cancer Genes supports a wide range of applications in cancer research and therapy development:

• Identification of potential biomarkers for cancer diagnosis and prognosis
• Discovery of new therapeutic targets for cancer treatment
• Understanding the genetic basis of cancer and its progression

Access

The NCG database is accessible online, offering free access to its content and tools for registered users. It serves as a valuable resource for the global research community, promoting the sharing of knowledge and collaboration in the fight against cancer.