Neuroblastoma ras viral oncogene homolog

Neuroblastoma ras viral oncogene homolog - human oncogene n-ras is a mutated variant of nras gene (ras family), which encodes p21 n-ras protein, a monomeric gtpase involved in transmembrane signal transduction that alternates between inactive gdp-bound and active gtp-bound forms. Ras is activated by a guanine nucleotide-exchange factor and inactivated by a gtpase-activating protein. Mitogen-stimulated ras stabilizes myc protein and enhances myc accumulation by the ras/raf/mapk pathway, which appears to inhibit the proteasome-dependent degradation of myc. Implicated in a variety of human tumors, specific amino acid mutations activate c-ras and transform cells. Oncogene nras disrupts normal cell function.