Neuroblastoma ras viral oncogene homolog

Neuroblastoma ras viral oncogene homolog - human oncogene n-ras is a mutated variant of nras gene (ras family), which encodes p21 n-ras protein, a monomeric gtpase involved in transmembrane signal transduction that alternates between inactive gdp-bound and active gtp-bound forms. Ras is activated by a guanine nucleotide-exchange factor and inactivated by a gtpase-activating protein. Mitogen-stimulated ras stabilizes myc protein and enhances myc accumulation by the ras/raf/mapk pathway, which appears to inhibit the proteasome-dependent degradation of myc. Implicated in a variety of human tumors, specific amino acid mutations activate c-ras and transform cells. Oncogene nras disrupts normal cell function.

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian