Neuropeptide FF receptor 2

Neuropeptide FF receptor 2 (NPFFR2), also known as G-protein coupled receptor 74 (GPR74), is a protein that in humans is encoded by the NPFFR2 gene. This receptor is a member of the G protein-coupled receptor (GPCR) family, which plays a critical role in signal transduction across cell membranes. NPFFR2 specifically binds to neuropeptides such as Neuropeptide FF and Neuropeptide AF, which are involved in a variety of physiological processes including pain modulation, cardiovascular system regulation, and hormonal regulation.

Function

NPFFR2 is predominantly expressed in the central nervous system (CNS), including areas such as the hypothalamus and spinal cord, where it is involved in the modulation of pain and the opioid system. Activation of NPFFR2 by its ligands has been shown to produce anti-opioid effects, which can modulate the analgesic effects of opioids and potentially contribute to the development of opioid tolerance. Furthermore, NPFFR2 and its ligands are implicated in the regulation of feeding behavior and energy homeostasis, suggesting a role in the control of body weight and metabolism.

Clinical Significance

Given its role in pain modulation and the opioid system, NPFFR2 is of interest in the research of new analgesics and treatments for opioid addiction and tolerance. Additionally, due to its involvement in regulating feeding behavior, NPFFR2 is a potential target for the development of treatments for obesity and metabolic disorders.

Ligands

Several synthetic ligands have been developed to study the function of NPFFR2, including agonists and antagonists. These compounds have been useful in elucidating the physiological and pharmacological roles of NPFFR2, as well as in exploring its potential as a therapeutic target.

See Also

• Neuropeptide FF receptor 1
• G protein-coupled receptor
• Neuropeptide FF
• Opioid receptor