Neutrophil extracellular traps

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Agregation of neutrophils around spontaneously activated netosis observed in Alzheimers' Desease patients blood

Neutrophil extracellular traps (NETs) are web-like structures composed of neutrophil chromatin and granule proteins that are released by activated neutrophils in response to various stimuli. These structures play a crucial role in the immune response by trapping and killing pathogens, such as bacteria, fungi, and viruses. NETs are also involved in the pathogenesis of various diseases, including autoimmune disorders, cancer, and thrombosis.

The formation of NETs, known as NETosis, is a complex process that involves the activation of neutrophils and the release of their nuclear contents into the extracellular space. This process is triggered by various stimuli, including microbial products, cytokines, and oxidative stress. Once released, NETs can ensnare and kill pathogens through a combination of histones, DNA, and antimicrobial proteins.

While NETs play a crucial role in host defense, dysregulated NET formation has been implicated in the pathogenesis of several diseases. For example, excessive NET formation has been linked to the development of autoimmune disorders, such as systemic lupus erythematosus and rheumatoid arthritis. Additionally, NETs have been shown to promote thrombosis by activating platelets and the coagulation cascade.

Research into the role of NETs in disease pathogenesis is ongoing, with potential implications for the development of novel therapeutic strategies targeting NET formation and function. Understanding the complex interplay between NETs and the immune system may provide new insights into the treatment of various inflammatory and autoimmune conditions.

In conclusion, neutrophil extracellular traps are dynamic structures that play a dual role in host defense and disease pathogenesis. Further research into the mechanisms underlying NET formation and function may lead to the development of targeted therapies for a range of immune-mediated disorders.