Nicodicodeine
Nicodicodeine is an opioid analgesic and cough suppressant, an ester of dihydrocodeine similar to but more potent than dihydrocodeine. It is not commonly used. It is categorised as a Schedule I controlled substance in the United States, with an ACSCN of 9307 and a 2013 annual aggregate manufacturing quota of zero.
Pharmacology[edit | edit source]
Nicodicodeine is metabolised in the liver by demethylation to produce nicocodeine, and subsequently further metabolised to dihydrocodeine. It is also metabolised to dihydromorphine.
Chemistry[edit | edit source]
Nicodicodeine is almost always used as the hydrochloride salt, which has a free base conversion ratio of 0.914, the second highest of any opioid in common use.
See also[edit | edit source]
References[edit | edit source]
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