Nifekalant
Nifekalant is a Class III antiarrhythmic agent used primarily in the treatment of ventricular arrhythmias. It is marketed under the brand name AIF in Japan by Mitsubishi Tanabe Pharma. Nifekalant was approved for use in Japan in 1999.
Pharmacology[edit | edit source]
Nifekalant is a potassium channel blocker that prolongs the duration of the action potential and refractory period in myocardial cells. It selectively inhibits the rapid component of the delayed rectifier potassium current (IKr) in the heart, which can help to suppress ventricular tachycardia and ventricular fibrillation.
Clinical Use[edit | edit source]
Nifekalant is used in the treatment of life-threatening ventricular arrhythmias, such as ventricular tachycardia and ventricular fibrillation, particularly when these conditions are unresponsive to other antiarrhythmic drugs. It is administered intravenously in a hospital setting.
Side Effects[edit | edit source]
Common side effects of Nifekalant include bradycardia, hypotension, and QT interval prolongation. Less common side effects can include dizziness, nausea, and vomiting. Due to the risk of QT interval prolongation, Nifekalant should be used with caution in patients with a history of torsades de pointes or other serious heart conditions.
See Also[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
