Nifuroxazide

Nifuroxazide is an antibiotic primarily used to treat diarrhea caused by bacteria. It is a member of the nitrofuran class of antibiotics, which also includes drugs such as nitrofurantoin and furazolidone. Nifuroxazide is not absorbed from the gastrointestinal tract, which means it can act directly on the bacteria causing the infection without systemic side effects.

History

Nifuroxazide was first synthesized in the 1960s by the French pharmaceutical company Laboratoires Robert & Carrière. It has since been marketed under various brand names around the world, including Ercefuryl, Nifurox, and Diarstop.

Mechanism of Action

Nifuroxazide works by inhibiting the enzymes that bacteria use to produce energy, effectively starving them to death. It is particularly effective against E. coli, Shigella, and Salmonella, which are common causes of diarrhea.

Side Effects

Like all drugs, Nifuroxazide can cause side effects. These are generally mild and may include nausea, vomiting, and rash. In rare cases, it can cause a severe allergic reaction known as anaphylaxis.

Usage

Nifuroxazide is typically taken orally in the form of a capsule or suspension. The usual dose for adults is 200 mg four times a day, while children are usually given a lower dose. Treatment typically lasts for 5-7 days.

See Also

• Antibiotic
• Diarrhea
• Nitrofuran