Noggin (protein)

Noggin (protein) is a protein that in humans is encoded by the NOG gene. It is known for its role in the development of many body tissues, including nerve tissue, muscles, and bones.

Function

Noggin is a Bone Morphogenetic Protein (BMP) antagonist that is known to play a crucial role in neural tube formation, somite specification, and joint formation. It functions by binding to BMPs and preventing them from interacting with their receptors. This inhibits BMP signaling pathway, which is important for the development and differentiation of cells in the body.

Structure

The Noggin protein is a homodimer, meaning it is composed of two identical subunits. Each subunit is made up of a single polypeptide chain, which folds into a specific three-dimensional shape. The two subunits are held together by disulfide bonds.

Clinical significance

Mutations in the NOG gene are associated with several congenital disorders, including symphalangism, brachydactyly, and multiple synostoses syndrome. These disorders are characterized by abnormalities in the development of the bones and joints.

See also

• Bone Morphogenetic Protein
• Congenital disorder
• Symphalangism
• Brachydactyly
• Multiple synostoses syndrome

External links

• GeneCards - NOG