Non-occlusive disease

Non-occlusive disease (NOD) or Non-occlusive mesenteric ischaemia (NOMI) is a life-threatening condition including all types of mesenteric ischemia without mesenteric obstruction. It affects mainly elderly patients above 50 years of age who suffer from cardiovascular disease (myocardial infarction, congestive heart failure or aortic regurgitation), hepatic, chronic kidney disease or diabetes mellitus. It can be triggered also by a previous cardiac surgery with a consequent heart shock.^[1]^[2] It represents around 20% of cases of acute mesenteric ischaemia.^[3]

Pathophysiology[edit | edit source]

Non-occlusive mesenteric ischemia occurs due to severe vasoconstriction of mesenteric vessels supplying the intestine. Acute abdominal pain is the only early acute symptom in those patients, which makes early diagnosis difficult.

Diagnosis[edit | edit source]

CT angiography would be helpful in differentiating occlusive from non-occlusive causes of mesenteric ischaemia.^[4]

Prognosis[edit | edit source]

Non-occlusive disease has a poor prognosis with survival rate between 40-50%.^[1]^[3]

References[edit | edit source]

↑ ^1.0 ^1.1
↑
↑ ^3.0 ^3.1 Longmore, Murray; Wilkinson, Ian; Baldwin, Andrew; Wallin, Elizabeth (31 March 2017). "Oxford Handbook of Clinical Medicine". OUP Oxford – via Google Books.
↑ Garden, O. James; Bradbury, Andrew W.; Forsythe, John L. R.; Parks, Rowan W. (28 May 2012). "Principles and Practice of Surgery E-Book: With STUDENT CONSULT Online Access". Elsevier Health Sciences – via Google Books.

Non-occlusive disease Resources
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