Normustine
Normustine is a nitrosourea compound that is used as a chemotherapeutic agent. It is classified as an alkylating agent, which means it works by damaging the DNA of cancer cells to prevent them from dividing and growing.
Mechanism of Action[edit | edit source]
Normustine, like other nitrosoureas, works by alkylating the DNA of cancer cells. This process involves the transfer of an alkyl group to the DNA molecule, which can cause breaks in the DNA strand and prevent the DNA from being properly replicated. This can lead to cell death, particularly in cells that are rapidly dividing, such as cancer cells.
Uses[edit | edit source]
Normustine is used in the treatment of various types of cancer, including brain tumors, Hodgkin's disease, non-Hodgkin's lymphoma, and lung cancer. It is often used in combination with other chemotherapeutic agents to increase its effectiveness.
Side Effects[edit | edit source]
Like all chemotherapeutic agents, normustine can cause a range of side effects. These can include nausea, vomiting, hair loss, and fatigue. More serious side effects can include bone marrow suppression, which can lead to an increased risk of infection, and neurotoxicity, which can cause problems with nerve function.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
