Noroxymorphone

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Noroxymorphone

Noroxymorphone is an opioid and analgesic drug that is used in the treatment of severe pain. It is a derivative of morphine and is considered to be one of the most potent opioids available.

Chemistry

Noroxymorphone is a semi-synthetic opioid that is derived from morphine. It is structurally similar to morphine, but has a hydroxyl group replaced with a ketone group. This modification increases the potency of the drug and reduces its side effects.

Pharmacology

Noroxymorphone works by binding to the mu-opioid receptor in the brain and spinal cord. This binding inhibits the transmission of pain signals and produces a feeling of euphoria. The drug has a high affinity for the mu-opioid receptor, which makes it more potent than morphine.

Clinical Use

Noroxymorphone is used in the treatment of severe pain that cannot be managed with other pain medications. It is often used in patients with cancer or those undergoing major surgery. The drug is usually administered by injection, but can also be taken orally.

Side Effects

Like all opioids, Noroxymorphone has a number of side effects. These can include nausea, vomiting, constipation, and drowsiness. In severe cases, the drug can cause respiratory depression, which can be life-threatening.

Addiction and Dependence

Long-term use of Noroxymorphone can lead to physical dependence and addiction. This is due to the drug's ability to produce a feeling of euphoria, which can lead to repeated use. Withdrawal symptoms can occur if the drug is stopped suddenly.

See Also

• Opioid
• Morphine
• Mu-opioid receptor