O-2050

From WikiMD's Wellness Encyclopedia

O-2050 is a synthetic cannabinoid that is used in scientific research. It is a selective agonist for the peripheral CB2 receptor, and has been used in a variety of studies to explore the role of this receptor in immune function, pain, and other physiological processes.

Chemistry[edit | edit source]

O-2050 is a member of the naphthoylindole family of synthetic cannabinoids. It is structurally similar to other cannabinoids such as JWH-018 and HU-210, but differs in that it has a sulfonamide group, which is believed to be responsible for its selectivity for the CB2 receptor.

Pharmacology[edit | edit source]

O-2050 acts as a selective agonist for the CB2 receptor, with a Ki value of 23.4 nM. This makes it one of the most potent CB2-selective agonists currently known. It has been shown to produce anti-inflammatory effects in animal models, and has also been used to study the role of the CB2 receptor in pain perception.

Research uses[edit | edit source]

Due to its selectivity for the CB2 receptor, O-2050 has been used in a variety of research studies. These have included investigations into the role of the CB2 receptor in immune function, the potential therapeutic uses of CB2 agonists in conditions such as chronic pain and inflammatory bowel disease, and the effects of CB2 activation on neuroinflammation and neurodegeneration.

See also[edit | edit source]

References[edit | edit source]


O-2050 Resources
Wikipedia
WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD