O-2172

O-2172 is a synthetic cannabinoid that is used in scientific research. It is a selective agonist for the peripheral cannabinoid receptor CB2, with much lower affinity for the central CB1 receptor.

Chemistry

O-2172 is part of a group of synthetic cannabinoids known as naphthoylindoles. These compounds are characterized by a naphthoyl group attached to an indole core. The specific structure of O-2172 consists of a naphthoyl group attached at the 3-position of the indole ring, with a secondary amide linkage to a cyclohexylmethyl tail.

Pharmacology

O-2172 acts as a selective agonist for the CB2 receptor, with a Ki value of 1.6 nM. It has 60 times lower affinity for the CB1 receptor, with a Ki value of 96 nM. This selectivity makes O-2172 useful for studying the role of CB2 receptors in the body, without the psychoactive effects associated with activation of CB1 receptors.

Uses in Research

Due to its selectivity for CB2 receptors, O-2172 has been used in research to study the role of these receptors in various physiological processes. This includes research into pain, inflammation, and immune system function. The compound has also been used to investigate the potential therapeutic benefits of CB2 receptor activation, such as in the treatment of chronic pain or autoimmune diseases.

Legal Status

As a synthetic cannabinoid, the legal status of O-2172 varies by country. In some jurisdictions, it may be considered a controlled substance. Researchers wishing to work with O-2172 should consult local regulations to ensure compliance.

See Also

• Cannabinoid receptor
• Synthetic cannabinoids
• Naphthoylindoles