OR10AG1

OR10AG1 is a gene that encodes a protein in humans. It is also known as olfactory receptor 10AG1. Olfactory receptors are proteins that bind odor molecules in the nose, initiating a neural response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes.

Function

The OR10AG1 gene is part of the olfactory receptor family, a class of receptors that play a fundamental role in the sense of smell. The olfactory receptors are located in the cell membranes of the olfactory receptor neurons and are responsible for the detection of odorants. These receptors are activated by the odorant molecules in the air, leading to a neuronal response and ultimately the perception of smell.

Structure

The OR10AG1 gene is located on chromosome 1, specifically at 1q44. It spans approximately 1 kilobase and consists of a single coding exon. The encoded protein is a member of the GPCR family, characterized by seven transmembrane domains, an extracellular N terminus, and an intracellular C terminus.

Clinical Significance

While the specific clinical significance of OR10AG1 is not fully understood, olfactory receptors in general are being studied for their potential roles in disease. Some olfactory receptors are known to be involved in disease processes, and alterations in olfactory receptor function can lead to disorders of smell perception, such as anosmia.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia