OR10H2

OR10H2 is a gene that encodes a protein in the olfactory receptor family. This family is responsible for the detection of odorants in the nose, and is the largest gene family in the mammalian genome. The OR10H2 gene is specifically involved in the detection of certain odorants, and variations in this gene can affect an individual's sense of smell.

Structure

The OR10H2 gene is located on chromosome 1, specifically at 1q44. It spans approximately 1 kilobase and contains one exon. The encoded protein is a member of the olfactory receptor family, and like other members of this family, it is a G-protein coupled receptor. This means that it spans the cell membrane seven times and is involved in signal transduction processes.

Function

The OR10H2 protein is expressed in the olfactory epithelium, where it is involved in the detection of odorants. When an odorant binds to the OR10H2 protein, it triggers a signal transduction pathway that ultimately leads to the perception of smell. The specific odorants that the OR10H2 protein can detect are not fully known, but research suggests that it may be involved in the detection of certain floral and fruity smells.

Clinical significance

Variations in the OR10H2 gene can affect an individual's sense of smell. For example, certain genetic variants can lead to a reduced ability to detect certain smells, a condition known as anosmia. Other variants can lead to an enhanced ability to detect certain smells. Research is ongoing to better understand the role of the OR10H2 gene in smell and how variations in this gene can affect smell perception.

See also

• Olfactory receptor
• Anosmia
• G protein-coupled receptor

References

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