OR10J5

OR10J5 is a protein that in humans is encoded by the OR10J5 gene. The protein is a member of the olfactory receptor family, which is involved in the detection of smell.

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Gene

The OR10J5 gene is located on chromosome 1, specifically at 1q44. It spans a length of approximately 1.1 kilobases and consists of a single coding exon. The gene is expressed in the olfactory epithelium, the tissue lining the nasal cavity that is involved in smell.

Clinical significance

While the exact role of OR10J5 in disease is not well understood, olfactory receptors in general have been implicated in a variety of diseases, including Parkinson's disease, Alzheimer's disease, and certain types of cancer. Further research is needed to determine the specific role of OR10J5 in these and other conditions.

See also

• Olfactory receptor
• G protein-coupled receptor
• 1q44 deletion syndrome

References

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