OR11H4

OR11H4 is a gene that encodes a protein in the olfactory receptor family. This gene is located on chromosome 14 in humans. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Function

The protein encoded by the OR11H4 gene is an olfactory receptor. Olfactory receptors (ORs) are a type of G protein-coupled receptor (GPCR) that are expressed in the cell membranes of olfactory receptor neurons and are responsible for the detection of odorants. When an odorant binds to an OR, it triggers a signal transduction cascade that results in a nerve impulse being sent to the brain.

Structure

The OR11H4 protein is a member of the olfactory receptor family, which is the largest family of GPCRs. Like all GPCRs, OR11H4 has a seven-transmembrane domain structure. This structure allows it to span the cell membrane and interact with odorant molecules on the outside of the cell and signal transduction machinery on the inside of the cell.

Clinical significance

While the specific role of OR11H4 in human health and disease is not yet fully understood, olfactory receptors in general are known to play a crucial role in the sense of smell. Mutations in olfactory receptor genes, including OR11H4, can lead to anosmia, which is the inability to perceive odor or a lack of functioning olfaction.

See also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia