OR12D3

OR12D3 is a gene that encodes a protein in humans. It is also known as Olfactory Receptor Family 12 Subfamily D Member 3. This gene is part of the olfactory receptor family, which is the largest gene family in the genome. The olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.

Function

The protein encoded by the OR12D3 gene is an olfactory receptor. Olfactory receptors are members of the G protein-coupled receptor superfamily. They are located in the cell membranes of olfactory receptor neurons and are involved in the detection of odorants.

Gene

The OR12D3 gene is located on chromosome 11, specifically at 11p15.4. It spans approximately 1.1 kilobases and consists of a single exon. The gene is expressed in the olfactory epithelium.

Clinical Significance

While the specific clinical significance of OR12D3 is not fully understood, olfactory receptors in general have been implicated in various diseases and conditions. For example, mutations in olfactory receptor genes have been associated with anosmia, a condition characterized by a loss of the sense of smell.

See Also

• Olfactory receptor
• Anosmia
• G protein-coupled receptor

References

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