OR13D1

OR13D1 is a gene that in humans is encoded by the OR13D1 protein. It is a member of the olfactory receptor family of genes, which are the largest gene family in the genome. The olfactory receptors (ORs) are G protein-coupled receptors that play a role in the detection of odorants.

Function

Olfactory receptors function by interacting with odorant molecules in the nose, initiating a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes.

Gene

The OR13D1 gene is located on chromosome 1, specifically at 1q44. It spans a length of approximately 1.1 kilobases and consists of a single coding exon. The gene is expressed in the olfactory epithelium.

Protein

The OR13D1 protein is a member of the G protein-coupled receptors (GPCRs) family. GPCRs are a large protein family of receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. They are integral membrane proteins that possess seven transmembrane domains.

Clinical significance

While the specific clinical significance of OR13D1 is not yet fully understood, olfactory receptors in general are thought to have roles in various diseases such as cancer, neurodegenerative diseases, and congenital anosmia (inability to smell).

See also

• Olfactory receptor
• G protein-coupled receptor
• Congenital anosmia