OR13F1

OR13F1 is a gene that encodes a protein in the olfactory receptor family. This family is responsible for the detection of odorants in the nose, and is the largest gene family in the mammalian genome. The OR13F1 gene is specifically involved in the detection of certain odorants.

Function

The olfactory receptor proteins, such as the one encoded by the OR13F1 gene, are located in the cell membranes of olfactory receptor neurons in the nose. These proteins bind to specific odorant molecules, triggering a signal transduction pathway that results in the perception of smell. The specific odorants that the OR13F1 protein binds to are not yet known.

Structure

The OR13F1 protein, like all olfactory receptors, is a G protein-coupled receptor. This means it has seven transmembrane domains, with the N-terminus located outside the cell and the C-terminus inside the cell. The specific structure of the OR13F1 protein has not yet been determined.

Expression

The OR13F1 gene is expressed in the olfactory epithelium, a specialized tissue inside the nose that contains the olfactory receptor neurons. The level of expression of the OR13F1 gene can vary between individuals, and this may contribute to differences in smell perception.

Clinical significance

Mutations in the OR13F1 gene, like mutations in other olfactory receptor genes, can lead to a reduced ability to smell, a condition known as anosmia. However, the specific clinical significance of the OR13F1 gene is not yet known.

See also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia