OR1A2
OR1A2 is a gene that encodes the olfactory receptor 1A2 protein in humans. The olfactory receptor family is the largest in the genome, with members located on almost all human chromosomes.
Function[edit | edit source]
The olfactory system is a sensory system used for the sense of smell (olfaction). Olfactory receptors, such as OR1A2, are proteins that bind odor molecules resulting in a neuronal response which allows the perception of smell. These receptors are expressed in the cilia of the olfactory sensory neurons.
Gene[edit | edit source]
The OR1A2 gene is located on chromosome 11, specifically at 11p15.4. It spans approximately 1 kilobase and consists of a single coding exon. The OR1A2 gene is a member of the olfactory receptor family, and is part of the 1A subfamily.
Protein Structure[edit | edit source]
The OR1A2 protein is a member of the class A rhodopsin-like family of G protein-coupled receptors. It is composed of 312 amino acids and has a molecular weight of approximately 35 kDa. The protein has seven transmembrane domains, a characteristic feature of G protein-coupled receptors.
Clinical Significance[edit | edit source]
Variations in the OR1A2 gene have been associated with differences in the sense of smell. Certain single nucleotide polymorphisms (SNPs) in this gene have been linked to a heightened sensitivity to certain odors.
See Also[edit | edit source]
References[edit | edit source]
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Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD