OR1D5

OR1D5 is a gene that encodes the olfactory receptor 1D5 in humans. The olfactory receptor family is the largest in the genome. The olfactory receptors (ORs) are G protein-coupled receptors (GPCRs) that play a role in the detection of odor molecules.

Function

The OR1D5 gene is part of the olfactory receptor family, a class of genes that are responsible for our sense of smell. These receptors are located in the olfactory epithelium, a small patch of tissue inside the nose. When an odor molecule binds to an olfactory receptor, it triggers a nerve impulse that is sent to the brain, which interprets the signal as a distinct smell.

Structure

The OR1D5 gene is located on chromosome 1, specifically on the long (q) arm at position 23.2. The gene spans approximately 1.1 kilobases and consists of a single exon. The encoded protein is a member of the G protein-coupled receptor 1 family. Like all GPCRs, OR1D5 has seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus.

Clinical Significance

While the exact role of OR1D5 in disease is not well understood, olfactory receptors in general have been implicated in a variety of conditions. For example, mutations in olfactory receptor genes have been associated with anosmia, a condition characterized by a loss of the sense of smell. Additionally, some studies suggest that olfactory receptors may play a role in cancer, as they have been found to be overexpressed in certain types of tumors.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia

References

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