OR1E1

OR1E1 is a gene that encodes the olfactory receptor protein 1E1 in humans. The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Structure

The OR1E1 gene is located on chromosome 1, specifically at 1q23.1. The gene spans approximately 1 kilobase and consists of a single coding exon. The OR1E1 protein is a member of the Class A rhodopsin-like family of GPCRs, which is characterized by a 7-transmembrane domain structure.

Function

The primary function of the OR1E1 protein is the detection of odorants. Odorant molecules bind to the OR1E1 receptor in the olfactory epithelium, triggering a signal transduction pathway that results in the perception of smell. The specific ligands that bind to the OR1E1 receptor are not yet known.

Clinical Significance

While the OR1E1 gene is not currently associated with any specific diseases, olfactory receptors in general have been implicated in a variety of health conditions. For example, alterations in olfactory receptor function can lead to anosmia, the inability to perceive odor. Additionally, some olfactory receptors are expressed in other tissues and have been linked to cancer, metabolic disorders, and other diseases.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia

References

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