OR1G1

OR1G1 is a gene that encodes a protein in humans. It is also known as Olfactory Receptor, Family 1, Subfamily G, Member 1. This gene is part of the olfactory receptor family, which is the largest gene family in the genome. The olfactory receptors olfactory receptors are G protein-coupled receptors that are involved in the detection of smell.

Function

The OR1G1 gene is a member of the olfactory receptor family and is expressed in the olfactory epithelium. It is involved in the detection of odorants and the transduction of odor signals. The protein encoded by this gene is thought to interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell.

Structure

The OR1G1 gene is located on chromosome 1, specifically on the long (q) arm at position 23.2. The gene spans approximately 1.1 kilobases and consists of a single exon. The protein encoded by this gene is a member of the G protein-coupled receptor family, which is characterized by seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus.

Clinical Significance

While the exact role of OR1G1 in disease is not well understood, olfactory receptors in general have been implicated in a variety of diseases, including neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, as well as cancer. Further research is needed to elucidate the specific role of OR1G1 in human health and disease.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Alzheimer's disease
• Parkinson's disease

References

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