OR1I1

OR1I1 is a gene that encodes the olfactory receptor 1I1 in humans. The olfactory receptor family is believed to be the largest gene family in the human genome. These receptors are responsible for the detection of odor molecules, playing a crucial role in the sense of smell (olfaction).

Function

The OR1I1 gene is part of the olfactory receptor family, a class of proteins that are involved in sensory perception. These receptors are located in the cell membranes of olfactory receptor neurons and are responsible for the detection of odorants, which are inhaled and then bind to these receptors within the nasal epithelium.

Structure

The OR1I1 gene is located on chromosome 6, specifically at 6q27. The gene spans approximately 1.1 kilobases and consists of a single exon. The encoded protein is a member of the class A rhodopsin-like family of G protein-coupled receptors.

Clinical Significance

While the specific clinical significance of OR1I1 is not fully understood, olfactory receptors in general have been implicated in various diseases and conditions. For example, mutations in olfactory receptor genes have been associated with a decreased sense of smell (anosmia). Additionally, some studies suggest that olfactory receptors may play a role in cancer, as they have been found to be expressed in a variety of tumor cells.

Research

Research into the OR1I1 gene and its encoded protein is ongoing. Understanding the specific roles and mechanisms of olfactory receptors like OR1I1 may provide insights into the complex processes of smell and potentially lead to the development of new therapeutic strategies for conditions related to olfaction.

See Also

• Olfactory receptor
• Olfaction
• Anosmia
• G protein-coupled receptor