OR1J1

OR1J1 is a gene that in humans is encoded by the OR1J1 olfactory receptor family 1 subfamily J member 1. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Structure

The OR1J1 gene is located on chromosome 1, specifically 1q44. It spans a length of approximately 1.1 kb and consists of a single coding exon. The encoded protein is 312 amino acids in length with a predicted molecular weight of approximately 34.5 kDa.

Function

The OR1J1 protein is a member of the olfactory receptor family of G-protein-coupled receptors. Olfactory receptors are responsible for the detection of odor molecules in the nose and the subsequent transduction of the odorant signal to the brain. The specific function of OR1J1 in odor detection is not yet fully understood.

Clinical Significance

While the specific clinical significance of OR1J1 is not yet fully understood, olfactory receptors in general have been implicated in a variety of diseases and conditions, including congenital anosmia, and neurodegenerative diseases such as Alzheimer's and Parkinson's.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia
• Alzheimer's disease
• Parkinson's disease

References

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